Ferula hermonis research and review
An intriguing study in male rats showed that Ferula hermonis, when given one
time, enhanced sexual activity, and also raised blood levels of testosterone.
However, when Ferula hermonis was given daily for 10 days, it actually reduced
sexual activity, and also reduced testosterone levels. This is difficult to
explain but my guess would be that perhaps the dose given to the rats was too
high.
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Compounds found in Ferula
hermonis
herb
Ferula hermonis extract has sesquiterpenes called
ferutinin, teferin and teferdin.
Role of ferutinin in the impairment of female
sexual function induced by Ferula hermonis.
Physiol Behav. 2006. Zavatti M, Montanari C, Zanoli
P. Department of Biomedical Sciences, Section of Pharmacology, and National
InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN),
University of Modena and Reggio Emilia, Italy.
In the present study, we evaluated the effects of single components of
Ferula hermonis extract on female rat sexual behavior. Ovariectomized rats
hormonally primed with estradiol benzoate and progesterone were acutely treated
by oral gavage with ferutinin, teferin and teferdin. Thereafter they were tested
for: a) partner preference, b) receptivity, c) proceptivity, d) paced mating
behavior. In the partner preference test, the choice of the female for a
sexually active male was not influenced by the different treatments. Similarly,
during the paced mating test, the contact-return latencies as well as the
percentage of exits from the male compartment were not different in control and
treated rats. Therefore none of the three compounds showed the capacity to alter
sexual motivation. On the other hand, ferutinin, but not teferin and teferdin,
significantly inhibited female receptivity. These results suggest a primary role
of ferutinin in the impairment of sexual behaviour elicited by Ferula hermonis
extract in hormone primed-female rats.
Ferula hermonis Research study
Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats.
Int J Impot Res. 2003.
Sexually potent and sluggish/impotent male rats were orally treated with an
extract of Ferula hermonis (30 and 60 mg/kg). The acute Ferula hermonis administration
stimulated sexual motivation in potent rats and improved copulatory performance
in sluggish/impotent rats. This last effect was elicited only by the higher
Ferula hermonis dose, which, in parallel, increased serum testosterone levels in rats. On the
contrary, when the extract was subchronically administered (10 days) a marked
reduction in the percentage of rats achieving ejaculation was detected, together
with a general impairment of the copulatory pattern. Furthermore, the repeated
administration of the Ferula hermonis extract (6 mg/kg/day for 10 days) resulted in a
significant reduction of testosterone levels in comparison with controls. The
present results discourage a repeated assumption of Ferula hermonis, while
suggesting its acute administration to improve the performance in sexual
dysfunctions.
Comments: it appears that Ferula hermonis is more suited for
short term use and not necessarily appropriate for long term sexual health. One
option is to use a Ferula hermonis supplement for a few days and then take a couple of
week or more off.
A comparative study of Ferula hermonis root extracts and sildenafil on
copulatory behavior of male rats.
Fitoterapia. 2003.
The effect of 600 mg/kg given by oral route to rats of Ferula hermonis roots
extracts was evaluated on
sexual behavior of male rats. Petroleum ether and ethyl acetate extracts
of Ferula hermonis produced a significant decrease in both the mount rate (MR) and the intromission
rate (IR), significant prolongation of intromission latency (IL) was observed
when these extracts were compared with both controls and sildenafil. Methanolic
Ferula hermonis
extract produced a significant increase in MR while no effect has been observed
on IR or IL in comparison with control. The effect of Ferula hermonis water extract was not
significantly different from controls for the MR and IR, but there was a
significant prolongation in the IL.